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Background: The regulated degradation of intracellular proteins plays an essential role in most biological processes, particularly in the control of cell proliferation and differentiation. In eukaryotes, intracellular proteolysis is largely mediated by the ubiquitin-proteasome system. Numerous dysfunctions of the degradation machinery have been linked to human diseases, particularly hematological malignancies. Objectives: The objective of our study is to detect a possible relationship between the onset of certain blood cancers and the aging process, through changes in the proteasome. Methodology: Quantitative and functional analysis of the proteasome was performed at the subcellular and serum levels during physiological (aging) and pathological (malignant hematological disease) conditions, using the sandwich ELISA technique and by monitoring the fluorescence emitted after enzymatic digestion of fluorogenic peptides specific to chymotrypsin-like activity. The CMF technique demonstrated the process of transmembrane migration of prosomal subunits originating from.
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