Process model adaption

Bioprocesses, in which gases serve as substrates, have become popular in the past years, as they are used, for example, to upgrade industrial exhaust gases. In this book, first a regulatory concept for the autotrophic cultivation of the bacterium Ralstonia eutropha is presented. The focus lies on a model-based gas phase controller that works independently of the strain. It adjusts the gas composition in the reactor headspace and maintains the desired excess pressure. The gas phase controller is framed by the general, model-based control system for process optimization. The second part deals with rapid model adaption for genetically modified strains. For process optimization, strain-dependent process models are used. Thus, the general process model has to be modified and reformulated for each strain before it can be utilized for model-based optimization. In order to shorten the labour-intensive, iterative step of modeling, different adaption methods were developed and applied. The combination of a strain-independent gas phase control and a toolbox for fast adaption of the process model of genetically modified strains, enables a fast and resource-saving process adaption.