Genome Damage

Genome Damage: Repair and Adaptation across Life explores the significance of nucleic acid damage from environmental pollutants, UV radiation and other stressors, which can lead to mutations, genetic instability, and various diseases, including cancer. This book delves into the mechanisms of DNA and RNA repair, which are crucial for maintaining cellular health and enabling evolutionary adaptations. The book examines these intricate processes across microbes, plants, and animals, providing a comprehensive understanding of how genetic materials are regulated and repaired under diverse environmental conditions. It covers a wide range of topics, including advanced molecular mechanisms of nucleotide repair, UV-induced damage, apoptosis cell death and autophagy, genetic instability in crops, and the role of post-translational modifications in DNA repair. The text also explores the detection and quantification of DNA damage, the impact of synthetic chemicals and climate change on nucleic acids, and the therapeutic significance of DNA repair mechanisms. The book closes with a look towards future perspectives. Genome Damage: Repair and Adaptation across Life is an invaluable resource for students, researchers, and professionals in molecular biology, cytogenetics, genomics, microbiology, ecotoxicology, plant biotechnology and the pharmaceutical industry. It is particularly beneficial for those studying the molecular mechanisms of DNA damage from an evolutionary perspective and those developing therapeutic strategies for cancer, oxidative diseases, and aging-related disorders.

• Covers nucleic acid damage and repair mechanisms across a range of organisms
• Provides insights into environmental adaptability and evolutionary significance of genetic mutations
• Discusses detection and prevention strategies for DNA damage
• Offers therapeutic applications for genetic disorders, including cancer and aging-related diseases