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Gastrointestinal patch systems have emerged as potential drug delivery systems for drugs having challenges with conventional drug delivery systems. Its integrated multifunction could overcome these challenges by providing bioadhesion, drug protection and unidirectional release. This combination of function could improve the overall oral bioavailability of large molecules such as proteins and peptides that can currently be delivered only by injection. Furthermore, gated hydrogel patch system produce complex pulsatile release patterns and could mimic more naturally the way in which the body produces compounds, such as insulin and some hormones. This self-regulated release and cell-specific targeting have the potential to provide additional impudent characteristics to this innovative therapeutic platform.
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