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Brezplačna dostava za naročila nad 69,99 € na prevzemna mesta DPD in Express One.

DNA Replicons - Next-generation Vaccines against Allergy

Name: DNA Replicons - Next-generation Vaccines against Allergy
Brand: VDM Verlag Dr. Mueller E.K.
SKU: 06943333
Price: 58.83 EUR
Availability: InStock
Author: Maximilian Gabler
ISBN: 9783836495554

Maximilian Gabler

Jezik

Angleščina

Knjiga Mehka

Koda Libristo: 06943333

Založba VDM Verlag Dr. Mueller E.K., april 2008

In this study, DNA vaccines based on alphaviral replicases (DNA replicons) were evaluated with respe... Celoten opis

Koda Libristo: 06943333

142 b

58.83 €

Na zalogi pri dobavitelju Odposlali bomo v 14-21 dneh

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In this study, DNA vaccines based on alphaviral replicases (DNA replicons) were evaluated with respect to their protective and therapeutic capacity for treatment of type I allergy. DNA replicons display specific danger signals and offer an excellent safety profile based on apoptotic elimination of transfected host cells thereby preventing undesirable long-term expression of the transfected gene. Using the model allergen beta-Galactosidase in a protective approach, the results showed that a replicase-based DNA vaccine can induce a comparable immune response at a more than 1000-fold lower dose than a conventional DNA vaccine. DNA replicon doses as low as 10 ng significantly prevented from IgE induction by subcutaneous protein sensitization. Furthermore, in a therapeutic approach with the same construct, DNA replicons balanced an ongoing allergic response. These data were confirmed with a DNA replicon encoding the clinically relevant timothy grass pollen allergen Phl p 5. In addition, lung pathology could be prevented by pre-vaccination with DNA replicons as measured by the magnitude of eosinophilia, goblet cell hyperplasia, IL-5 production and proliferation of endothelial cells.