Application of Solid-State Kinetics to Desolvation Reactions

The book presents an overview of the solid-state§kinetic literature including methodologies used,§mathematical derivations and pharmaceutical§applications. §§The book investigates the relationship between§calculation methods and artifactual results observed§in solid-state kinetics. A new approach is proposed§for evaluating solid-state kinetic data, this§approach combines modelistic and model-free methods§in a complimentary manner to achieve consistent§kinetic results.§§Experimental data focused on studying the solid-state§stability of several structurally§related solvates of sulfameter§(5 methoxysulfadiazine), this was done by studying§the kinetics of their desolvation reaction both§isothermally and nonisothermally. Calculated kinetic§parameters were compared and related to the crystal§structure of these solvates. A relationship was§established between desolvation kinetic parameters§(e.g., activation energy) and the solvent size. The§solid-state reaction models selected also§corresponded to the single crystal structure of the§sulfameter-solvate system. The book presents an overview of the solid-state§kinetic literature including methodologies used,§mathematical derivations and pharmaceutical§applications. §The book investigates the relationship between§calculation methods and artifactual results observed§in solid-state kinetics. A new approach is proposed§for evaluating solid-state kinetic data, this§approach combines modelistic and model-free methods§in a complimentary manner to achieve consistent§kinetic results.§Experimental data focused on studying the solid-state§stability of several structurally§related solvates of sulfameter§(5 methoxysulfadiazine), this was done by studying§the kinetics of their desolvation reaction both§isothermally and nonisothermally. Calculated kinetic§parameters were compared and related to the crystal§structure of these solvates. A relationship was§established between desolvation kinetic parameters§(e.g., activation energy) and the solvent size. The§solid-state reaction models selected also§corresponded to the single crystal structure of the§sulfameter-solvate system.